College football odds, picks, predictions for Week 2, 2022: Proven simulation backing Pittsburgh, Iowa State

No. 16 Arkansas opened its season with an impressive win over then-No. 23 Cincinnati last week, but the Razorbacks will have to back up that performance when they host South Carolina on Saturday afternoon during the Week 2 college football schedule. South Carolina got off to a strong start of its own, easily covering the 12.5-point spread in a 35-14 win over Georgia State. The Gamecocks have won the past three meetings against Arkansas, but the Razorbacks hold a 13-10 edge in the all-time series. Caesars Sportsbook has Arkansas listed as an 8.5-point favorite in the latest Week 2 college football odds.

Another SEC showdown in Week 2 pits No. 12 Florida vs. No. 20 Kentucky on Saturday night. The Gators are 5.5-point home favorites in the Week 2 college football spreads, but which team should you back with your Week 2 college football bets? Before locking in any Week 2 college football picks for those games or others, be sure to see the latest college football predictions from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 2 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 2

One of the college picks the model is high on in Week 2: The Pittsburgh Panthers (+6) stay within the spread against the Tennessee Volunteers in a 3:30 p.m. ET matchup at Acrisure Stadium in Pittsburgh. Tennessee cruised to a 59-10 win over Ball State last week, but Pittsburgh picked up a win over a quality opponent with its 38-31 victory against West Virginia.

The Panthers are going to be a much stiffer test for Tennessee than what it faced last week, especially considering that Pittsburgh notched a 41-34 win at Neyland Stadium when these teams met last year. Transfer quarterback Kedon Slovis completed 16 of 24 passes for 308 yards and a touchdown against West Virginia, marking the highest passing yardage by a Panthers quarterback in a season opener since 1998.

SportsLine’s model projects Slovis to go over 300 yards against a questionable Tennessee defense on Saturday, throwing two touchdowns along the way. Meanwhile, the model has Vols quarterback Hendon Hooker tossing an interception against a Pittsburgh defense that has scored in three straight games dating back to last season. The potential of a defensive touchdown is one reason why the Panthers are covering the spread in well over 50% of simulations. 

The Cyclones haven’t played at Iowa since 2018, and haven’t covered the spread at Kinnick since 2014. This year could be a different story, however, after Iowa stumbled out of the gates with an uninspiring 7-3 win against South Dakota State to open the season. The Hawkeyes kept the FCS program to just 120 yards on offense, but only put up 166 offensive yards of their own.

The model predicts that Iowa quarterback Spencer Petras will have another underwhelming showing on Saturday, and barely clear 175 passing yards. Meanwhile, Dekkers should power the Cyclones offense enough to keep things within a field goal, as the Cyclones cover in more than 50% of simulations. See which other teams the model likes here.

How to make college football picks for Week 2

The model has also made the call on who wins and covers in every other FBS matchup in Week 2, and it’s calling for multiple outright upsets. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which favorites will go down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,500 in profit over the past six-plus seasons, and find out.

College football odds for Week 2 (via Caesars)

See full Week 2 college football picks, odds, predictions here

Saturday, Sept. 10

Alabama at Texas (+20.5, 64.5)

Featured Game | Texas Longhorns vs. Alabama Crimson Tide

South Carolina at Arkansas (-8.5, 52.5)

Featured Game | Arkansas Razorbacks vs. South Carolina Gamecocks

Arkansas State at Ohio State (-44.5, 68.5)

Tennessee at Pittsburgh (+6, 64.5)

Featured Game | Pittsburgh Panthers vs. Tennessee Volunteers

Iowa State at Iowa (-3.5, 41.5)

Featured Game | Iowa Hawkeyes vs. Iowa State Cyclones

Virginia at Illinois (-4.5, 54)

Featured Game | Illinois Fighting Illini vs. Virginia Cavaliers

Kentucky at Florida (-5, 51.5)

Featured Game | Florida Gators vs. Kentucky Wildcats

Arizona State at Oklahoma State (-11, 54.5)

Featured Game | Oklahoma State Cowboys vs. Arizona State Sun Devils

USC at Stanford (+9, 65.5)

Featured Game | Stanford Cardinal vs. USC Trojans

Baylor at BYU (-2.5, 53.5)

Featured Game | BYU Cougars vs. Baylor Bears